SCr (mg/dl)

eGFR (mL/min)

Mean ± SE

Mean ± SE

Cycle 1 Day 8

0.69 ± 0.15

87.8 ± 12.4

Cycle 1 Day 15

0.93 ± 0.24

72.5 ± 15.6

Cycle 1 Day 22

0.74 ± 0.12

76.2 ± 16.0

Cycle 2 Day 8

0.82 ± 0.22

74.6 ± 16.6

Cycle 3 Day 8

0.84 ± 0.24

76.3 ± 15.7

Cycle 4 Day 8

0.79 ± 0.27

83.8 ± 15.8

Cycle 5 Day 8

0.85 ± 0.24

67.3 ± 13.5

Cycle 6 Day 8

0.83 ± 0.23

69.5 ± 16.3

Cycle 7 Day 8

0.92 ± 0.32

68.0 ± 19.1

Cycle 8 Day 8

0.96 ± 0.33

66.5 ± 23.3